Anti-MBTPS1 Antibody

Product Name

Anti-MBTPS1 Antibody

View all MBTPS1 Antibodies

SKU/Catalog Number

A06735

Size

100 µl

Form

Liquid

Description

Boster Bio Anti-MBTPS1 Antibody (Catalog # A06735). Tested in WB applications. This antibody reacts with Human, Mouse, Rat.

Storage & Handling

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

Cite This Product

Anti-MBTPS1 Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # A06735)

Host

Rabbit

Contents

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Clonality

Polyclonal

Isotype

IgG

Immunogen

Synthesized peptide derived from C-terminal of human MBTPS1.

*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.

Reactive Species

A06735 is reactive to MBTPS1 in Human, Mouse, Rat

Applications

A06735 is guaranteed for WB Boster Guarantee

Observed Molecular Weight

Calculated molecular weight

117.749kDa

Background of MBTPS1

Serine protease that catalyzes the first step in the proteolytic activation of the sterol regulatory element-binding proteins (SREBPs). Other known substrates are BDNF, GNPTAB and ATF6. Cleaves after hydrophobic or small residues, provided that Arg or Lys is in position P4. Cleaves known substrates after Arg-Ser-Val-Leu (SERBP-2), Arg-His-Leu-Leu (ATF6), Arg-Gly-Leu-Thr (BDNF) and its own propeptide after Arg-Arg-Leu-Leu. Mediates the protein cleavage of GNPTAB into subunit alpha and beta, thereby participating in biogenesis of lysosomes.

Nakajima T., J. Hum. Genet. 45:212-217(2000).
Nagase T., DNA Res. 2:37-43(1995).
Bechtel S., BMC Genomics 8:399-399(2007).

Antibody Validation

Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.

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Assay Dilutions Recommendation

The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.

Western blotting: 1:500~1:3000

Validation Images & Assay Conditions

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Western blot analysis of extracts from Jurkat/COLO205 cells, using MBTPS1 antibody A06735.

Gene/Protein Information For MBTPS1 (Source: Uniprot.org, NCBI)

Alternative Names

EC 3.4.21.112; Endopeptidase S1P; KIAA0091MGC138712; membrane-bound transcription factor peptidase, site 1; membrane-bound transcription factor protease, site 1; PCSK8; S1PMGC138711; site-1 protease; SKI1; SKI-1membrane-bound transcription factor site-1 protease; subtilisin/kexin isozyme-1; Subtilisin/kexin-isozyme 1 MBTPS1 PCSK8, S1P, SEDKF, SKI-1 membrane bound transcription factor peptidase, site 1 membrane-bound transcription factor site-1 protease|endopeptidase S1P|proprotein convertase subtilisin/kexin type 8|site-1 protease|subtilisin/kexin isozyme-1

For more info on MBTPS1, check out the MBTPS1 Infographic

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In this infographic, you will see the following information for MBTPS1: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].

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